Scientist II / Scientist III/ Senior ScientistDescription: TEGA Therapeutics, Inc. combines expertise in glycobiology, cell engineering and drug discovery to develop therapies for glycan (polysaccharide) related diseases and to develop glycan related therapeutics. As a class of molecules, glycans are much less frequently targeted in the pharmaceutical industry relative to proteins and nucleic acids however glycans play as many important cellular physiological and pathophysiological roles as proteins. Perhaps one notable exception is heparin, a widely prescribed anticoagulant dosed over 300,000 times per day in the US alone. Research at TEGA involves engineering cells to produce glycans with specific therapeutic properties. Of course, as glycans are polysaccharides, there are no glycan genes, so development involves engineering genes that encode members of the glycan biosynthetic pathways. Research is also aimed at biological production and scaleup as current advances in biologic production have been exclusively aimed at protein production. Expertise in glycobiology is desirable but not required. Proficiency in genetic engineering and biochemical methods including molecular separation and purification, assay development and performance, and cell culture are required. Experience with bioreactor production is also desired. Grant writing experience is also desired. Qualifications: A PhD and 5 years of postdoctoral or industry experience or 10 years of industry experience with at least 5 years in a leadership role. Proficiency with several of the following technologies: molecular cloning. cell transfection/transduction technologies, and analytical methods such as HPLC, ELISA, qPCR, flow cytometry. Ability to plan projects and experiments based on literature reports. Careful work with attention to detail. Work independently as well as in a team as a collaborator as well as supervisor and teacher. Compensation:
To be considered for this position, applicants should send their CV (resume) and a cover letter to [email protected]. Alternatively, application materials can be mailed to: Charles A. Glass, PhD
Posted December 6, 2024 |
