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Postdoctoral position is available in the laboratory of Hamed Jafar-Nejad, M.D

A postdoctoral position is available in the laboratory of Hamed Jafar-Nejad, M.D., at the Department of Molecular & Human Genetics, Baylor College of Medicine. Our laboratory is interested in the role of glycosylation and deglycosylation in animal development and human disease. We use cell culture, Drosophila and mouse genetics to identify and characterize genetic modifiers of human disease genes, in hopes of shedding light on disease pathophysiology and establishing new therapeutic targets.  We closely collaborate with experts in carbohydrate biochemistry.  For details about Jafar-Nejad lab’s research interests, please visit https://www.bcm.edu/research/labs/hamed-jafar-nejad.

We have reported a mouse model for a developmental disorder called Alagille syndrome (ALGS; OMIM 118450), and identified a glycosyltransferase called Poglut1 as a dominant genetic suppressor of the biliary phenotypes in this ALGS model (Thakurdas et al, Hepatology, 2016).  We have also identified a transcription factor as a dominant modifier of the disease phenotypes, whose expression also shows a strong correlation with liver disease severity in human patients (unpublished data). Building on these observations, the Postdoctoral Fellow will examine the genetic and transcriptional network involved in ALGS liver abnormalities and will examine the potential utility of these observations for developing therapies for this disease. These studies are likely to provide fundamental insights into normal biliary development and biliary repair in disease contexts.

Experience in mouse genetics and mammalian cell culture is essential. Expertise in molecular biology and biochemistry is highly desired.  The ideal candidate will be a highly motivated, recent graduate with a strong publication record.

For more information and to submit an application, please click here.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.