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Staff Scientist - The Division of Intramural Research (DIR) of the National Institute of Dental and Craniofacial Research (NIDCR)

The Staff Scientist in this position will conduct independent research and mentor other laboratory trainees.

NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH, , BETHESDA, MARYLAND
 

Position Description:

The Division of Intramural Research (DIR) of the National Institute of Dental and Craniofacial Research (NIDCR) seeks an outstanding Staff Scientist to conduct studies to characterize the O-glycome, i.e. all known sites of mucin-type O-glycosylation in an organism. The O-glycome is defined by the substrate specificities of the multi-gene family of enzymes that catalyze the formation the core Ser/Thr-GalNAc linkage upon which O-glycans are built. Prior work from our group (https://irp.nih.gov/pi/lawrence-tabak - for example,  Fritz et al., Proc. Natl Acad. Sci. USA, 2004;101:15307; and, Raman et al., J. Biol. Chem. 2008;283:22942) together with more recent collaborative studies with the Drs. Kelly Ten Hagen and Nadine Samara (e.g. Ji et al., Nat Commun, 2018;9:3508) have defined the structural mechanisms that underlie the substrate specificities of these enzymes.

While approaches to delineating sites of O-glycosylation have been developed for simple, genetically engineered cell lines, to date there is no universal approach to study the entire O-glycome of a tissue extract or biological fluid. Therefore, our next goal is to develop appropriate chemical and/or enzymatic conditions that cleave O-glycans while leaving the modified core protein substrate assayable by mass spectrometry. In collaboration with the Ten Hagen lab (https://irp.nih.gov/pi/kelly-ten-hagen),  this platform will be used to deduce substrates contributing to biologically relevant phenotypes when specific GalNAc-Ts are genetically ablated in mice (e.g. Tian et al., PLoS One, 2015;10:e0115861) and flies (e.g. Zhang et al., Proc Natl Acad Sci U S A. 2014;111;7296). The successful candidate will have extensive experience in protein chemistry and analysis. Glycobiology and/or mass spectrometry experience would be a great asset as we will collaborate with Dr. Yan Wang who leads the NIDCR’s Mass Spec Facility. 

A Staff Scientist is a federal full-time equivalent position, that is time-limited and renewable, and a comprehensive benefits package is available. Salary is commensurate with qualifications and experience. Staff Scientists do not receive independent resources, although they often work independently and have sophisticated skills and knowledge essential to the work of the laboratory. Staff Scientists should be capable of independently designing experiments, but do not have responsibilities for initiating new research programs. The Staff Scientist in this position will conduct independent research and mentor other laboratory trainees.
 

Qualifications:

Candidates must possess a Ph.D. in chemistry, biochemistry, or a closely related field and at least 2 years of postdoctoral experience. An outstanding publication record in protein and/or analytical biochemistry is required together with evidence of excellent oral and written communication skills. Appointees may be US citizens, resident aliens, or non-resident aliens with or that are eligible to obtain a valid employment authorized visa.
 

To Apply:

Interested persons should submit one combined PDF of their curriculum vitae, a one-page statement of research background and interests, copies of their 3 most important scientific publications, and the name of three individuals who can serve as references. Please do not solicit letters of recommendation at this time. Please send all materials to:\

Dr. Lawrence Tabak electronically at: Lawrence.Tabak@nih.gov

Application packages will only be accepted electronically, and review of applications will begin on May 20th, and will continue to be accepted until the position is filled. Applications from women, minorities and persons with disabilities are strongly encouraged. HHS and NIH are Equal Opportunity Employers.